Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Escherichia coli replicates its genome through a finely tuned ensemble of proteins that assemble at the replication fork to form the replisome. Central to this machinery are the DNA polymerase III ...

Eukaryotic DNA replication is initiated at multiple origins through a tightly regulated sequence of events: origin licensing, helicase activation and assembly of the replisome. The replicative ...

Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus. The ...

A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. The study reveals a unique viral mechanism: a molecular ring anchors the viral copying machine ...